报告题目：Abnormal hemispheric asymmetry of both brain function and structure in ADHD: a meta-analysis study

报 告 人：郭水霞 教授 湖南师范大学

报告时间：2021年9月24日  10:30-11:30

报告地点：数学楼三楼研讨室5

校内联系人：朱复康 fzhu@jlu.edu.cn

报告摘要：Aberration in the asymmetric nature of the human brain is associated with several mental disorders, including attention deficit/hyperactivity disorder (ADHD). In this study, we applied a comprehensive meta-analysis to multimodal imaging datasets from 627 subjects (303 typically developing control and 324 patients with ADHD) with both resting-state functional and structural magnetic resonance imaging (MRI), from seven independent publicly available datasets of the ADHD-200 sample. We performed lateralization analysis and calculated the combined effects of ADHD on each of three cortical regional measures (grey matter volume - GMV, fractional amplitude of low frequency fluctuations at rest -fALFF, and regional homogeneity -ReHo). We found that compared with TDC, 68%, 73% and 66% of regions showed statistically significant ADHD disorder effects on the asymmetry of GMV, fALFF, and ReHo, respectively, Forty-one percent (41%) of regions had both structural and functional abnormalities in asymmetry, located in the prefrontal, frontal, and subcortical cortices, and the cerebellum. Furthermore, brain asymmetry indices in these regions were higher in children with more severe ADHD symptoms, indicating a crucial pathoplastic role for asymmetry.

报告人简介：郭水霞，湖南师范大学教授，博士生导师。湖南省芙蓉学者特聘教授、“统计学”湖南省国内一流学科带头人、“统计学”国家一流本科专业负责人、湖南师范大学“统计学”一级学科博士点负责人、湖南省杰出青年基金获得者。入选“教育部新世纪优秀人才培养计划”、湖南省“新世纪121工程人员”。研究方向为医学影像大数据的分析与应用，基于医学影像数据的精神疾病预测研究。主持国家自然科学基金4项，发表SCI论文30多篇。